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- TRADE NAME: Factive (LG Life Sciences)
- INDICATIONS: Infections due to various microorganisms
- CLASS: Antibiotic, Antibiotic; fluoroquinolone, Antimicrobial
- HALF-LIFE: 4–12 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Antacids, BCG Vaccine, Calcium salts, Corticosteroids, Didanosine, Dong Quai, Insulin, Iron salts, Magnesium salts, Mycophenolate, NSAIDs, Probenecid, Quinapril, Sevelamer, St John's Wort, Sucralfate, Sulfonylureas, Typhoid Vaccine, Vitamin K antagonists, Zinc
- See adverse reactions attributed to class:
Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.
Fluoroquinolones may exacerbate muscle weakness in persons with myasthenia gravis.
The incidence of rash increases significantly when duration of therapy exceeds seven days, reaching 7.4% at 14 days.
SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRIAL NERVOUS SYSTEM EFFECTS and EXACERBATION OF MYASTHENIA GRAVIS
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Page last updated 07/31/2023
